منابع مشابه
Metabotropic Glutamate Receptors
Metabotropic glutamate receptors (mGluR)s are G-protein-coupled receptors that function as modulators of synaptic function and glutamate transmission. Post-synaptically localized subtype 5 mGlu5 receptors are co-localized with adenosine A2a, dopamine, and N-methyl-D-aspartate (NMDA) receptors and regulate local protein synthesis and messenger RNA (mRNA) translation at synapses, and are thus ide...
متن کاملMetabotropic glutamate receptors inhibit microglial glutamate release
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential feedback of glutamate on this system. Several agonists of mGluRs (metabotropic glutamate receptors) were applied to primary rat microglia, and the ...
متن کاملMetabotropic glutamate receptors trigger postsynaptic protein synthesis.
K+ depolarization or addition of glutamate to a synaptoneurosome preparation triggers a rapid increase in size of polyribosomal aggregates isolated by centrifugation of lysate through 1 M sucrose. The profile of response to the glutamate analogues quisqualate, ibotenate, and 1-aminocyclopentane-1,3-dicarboxylate corresponds to that of metabotropic receptors. Glutamate stimulation is mimicked by...
متن کاملDimeric arrangement of metabotropic glutamate receptors
Glutamate Receptors: Implications about the Dimeric Arrangement and Rearrangement upon Ligand Bindings Masataka Yanagawa, Takahiro Yamashita, and Yoshinori Shichida* From Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. Running title: Comparative FRET analysis of mGluRs *Address correspondence to: Yoshinori Shichida, Department of Biophysics, Gradua...
متن کاملSpecial Issue on Metabotropic Glutamate Receptors: Editorial
The selection of articles in this special issue was solicited following the highly successful eighth International Meeting on Metabotropic Glutamate (mGlu) Receptors, held in Taormina (Italy) in October 2014, and organised under the chairmanship of Professor Ferdinando Nicoletti. All papers were written and submitted after the conclusion of the meeting and were independently peer-reviewed. As a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.606608